CA-BUSINESS Summary

TSX slumps as U.S. economic data, resources weigh

TORONTO (Reuters) - Canada's main stock market fell on Friday as natural resources stocks slumped and market sentiment turned negative following U.S. economic growth data that fell short of expectations. The U.S. gross domestic product expanded at a 2.5 percent rate, an increase from the fourth quarter, but shy of the 3 percent growth analysts were hoping for. The weaker-than-expected data in Canada's biggest trading partner weighed on Canadian stocks.

Growth falls short of forecasts, weakness ahead

WASHINGTON (Reuters) - Economic growth regained speed in the first quarter, but not as much as expected, heightening fears an already weakening economy could struggle to cope with deep government spending cuts and higher taxes. Gross domestic product expanded at a 2.5 percent annual rate, the Commerce Department said on Friday, after growth nearly stalled at 0.4 percent in the fourth quarter. Economists had expected a 3.0 percent growth pace.

Chevron profit pinched by cheaper oil, but beats estimates

(Reuters) - Lower oil prices hit Chevron Corp's quarterly profit as the second-largest U.S. oil company faced refinery downtime and higher operating costs in its home market, though its shares rose as the earnings topped expectations. Analysts cited foreign currency gains that gave the company a particular boost in the quarter.

Euro zone sees light at end of tunnel, pitfalls remain

BRUSSELS (Reuters) - There are no calls for celebration, no desire to relax in the corridors of Brussels but some officials believe the euro zone has turned a corner, sharpening the focus on longer-term reforms and structures. Despite a messy bailout of Cyprus, markets are calm, Ireland's rescue program is on track and Greece and Portugal, while still in recession, hope for a slow recovery next year.

TransCanada expects Keystone XL to be in service in H2 of 2015

(Reuters) - TransCanada Corp , Canada's No.2 pipeline company said it now expects its Keystone XL pipeline to be in service in the second half of 2015 as it awaits U.S. presidential approval. The company, which reported a 27 percent rise in first-quarter profit on Friday, said the delay could increase the cost of the $5.3 billion pipeline designed to deliver mostly Canadian and some U.S. crude oil to refiners in Texas and Louisiana.

Credit Suisse shareholders back pay plan

ZURICH (Reuters) - Credit Suisse investors backed a plan to issue new shares to pay staff bonuses after more than two hours of criticism from individual shareholders angered by high pay for executives at the bank. Just over 75 percent of votes were cast in favor of the plan at an investor meeting on Friday, despite a recommendation to reject it from shareholder advisory group ISS.

Japan's ANA to test fly Boeing 787 Dreamliner on Sunday

TOKYO (Reuters) - Japan's All Nippon Airways will conduct a test flight of Boeing Co's 787 Dreamliner on Sunday, as it prepares to bring back passengers on a plane that was grounded across the world following incidents of batteries overheating. The test flight by ANA, the Dreamliner's top customer, comes after U.S. and Japanese authorities gave approval for flights to resume and will be the first of some 230 flights the airline has planned before allowing the jet to carry passengers.

Union threatens Lufthansa with further strikes in wage dispute

FRANKFURT (Reuters) - A German trade union has threatened Lufthansa with another round of strikes if the airline fails to present a better pay offer when wage talks resume next week. "If Lufthansa continues to refuse to present a negotiable offer that secures jobs and increases wages appropriately, there will be more strikes," Verdi wage negotiator Christine Behle said on Friday.

BOJ in credibility test as divisions emerge over inflation target

TOKYO (Reuters) - Bank of Japan policymakers are divided over whether the central bank can meet its inflation target in two years, underlining concerns it has set an unrealistic goal in its battle to end 15 years of deflation despite plans for a massive burst of monetary stimulus. The central bank held off on offering any fresh policy initiatives following the April 4 policy meeting, when new Governor Haruhiko Kuroda stunned markets by promising to inject about $1.4 trillion into the economy to hit the 2 percent inflation target in roughly two years.

Microsoft gets upper hand in first Google patent trial

SEATTLE (Reuters) - Microsoft Corp came out on top in the first of two patent trials versus Google Inc's Motorola Mobility unit on Thursday, as a federal judge in Seattle ruled largely in its favor. U.S. District Judge James Robart in Seattle said Microsoft owed only a fraction of the royalties Motorola had claimed for use of its technology in Microsoft's Xbox console.

Source: http://news.yahoo.com/ca-business-summary-004019720--finance.html

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Video: Is the Downturn Here?

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Lorenzo Fertitta says women?s groups are being used as a pawn by unions in fight for MMA in NY

While on Laurence Holmes podcast on the Score on Monday night, he asked me how it was being a woman covering such a male-dominant sport as mixed martial arts. I answered that while there were some problems and I did come up against some jerks from time to time, MMA was fantastic to me. I pointed out that the few jerks were rarely fighters.

So imagine my surprise when I heard from women's groups that I've long respected that the sport I cover is full of negative attitudes against women. As New York debates legislation sanctioning MMA, women's groups have protested because of the "violent nature of MMA."

"Due to the violent nature of mixed martial arts and the surprisingly high incidence of unchallenged sexism and misogyny displayed by certain fighters, commentators and other public figures associated with this sport, the prospect of legalization in New York state raises legitimate concerns about the increased exposure of our children to this new and potentially very negative influence," stated a bill introduced Friday by state Sen. Liz Krueger, who represents much of Manhattan's east side.

Have MMA figures said and done terribly misogynistic things? Absolutely. But so have NFL players. So have NHL players. Both football and hockey also feature violent collisions and catastrophic injuries. Where are the protests to evict the Buffalo Bills or New York Rangers from the state?

UFC CEO Lorenzo Fertitta, who has been lobbying for MMA's sanctioning in New York for years, thinks that these women's groups are being used as a pawn by the Culinary Union.

?It?s actually kind of sad,? Fertitta said. ?These women?s organizations and women?s groups stand for great things ? yet they are being used as a pawn by the Culinary Union.?

The union has a beef with Fertitta and his brother Frank because they own the largest non-union casinos in Las Vegas. The union has contacted women's groups to bring their attention MMA's rise and possible sanctioning in New York. But what would make more sense for the union to focus on is that fighters don't have a collective bargaining agreement and aren't unionized.

Krueger and others have pointed to links between MMA and violence when no such link has been found. There is also no discussion of how MMA has empowered women as fighters, officials, media and fans, or how women have learned self defense techniques at MMA gyms across the country. Invicta FC, a promotion run by a woman that features women's bouts, must have escaped their view.

There are real problems facing women. Sexual violence, domestic abuse, unequal pay, unequal treatment in the workplace, sexual harassment, and many other serious issues face women every day. Let's focus on how we should solve those real issues, and not a sport that has no proven link to any of these problems.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/lorenzo-fertitta-says-women-groups-being-used-pawn-224954336--mma.html

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Cancer cells' Achilles' heel revealed

Apr. 24, 2013 ? Scientists from the Manchester Collaborative Centre for Inflammation Research (MCCIR) have discovered why a particular cancer drug is so effective at killing cells. Their findings could be used to aid the design of future cancer treatments.

Professor Daniel Davis and his team used high quality video imaging to investigate why the drug rituximab is so effective at killing cancerous B cells. It is widely used in the treatment of B cell malignancies, such as lymphoma and leukemia -- as well as in autoimmune diseases like rheumatoid arthritis.

Using high-powered laser-based microscopes, researchers made videos of the process by which rituximab binds to a diseased cell and then attracts white blood cells known as natural killer (NK) cells to attack. They discovered that rituximab tended to stick to one side of the cancer cell, forming a cap and drawing a number of proteins over to that side. It effectively created a front and back to the cell -- with a cluster of protein molecules massed on one side.

But what surprised the scientists most was how this changed the effectiveness of natural killer cells in destroying these diseased cells. When the NK cell latched onto the rituximab cap on the B cell, it had an 80% success rate at killing the cell. In contrast, when the B cell lacked this cluster of proteins on one side, it was killed only 40% of the time.

Professor Davis says: "These results were really unexpected. It was only possible for us to unravel the mystery of why this drug was so effective, through the use of video microscopy. By watching what happened within the cells we could clearly identify just why rituximab is such an effective drug -- because it tended to reorganise the cancerous cell and make it especially prone to being killed."

He continues: "What our findings demonstrate is that this ability to polarise a cell by moving proteins within it should be taken into consideration when new antibodies are being tested as potential treatments for cancer cells. It appears that they can be up to twice as effective if they bind to a cell and reorganise it."

The findings from this study have been published online today on the website of the journal Blood. The research was carried out in collaboration with MedImmune, the global biologics research and development arm of AstraZeneca.

Commenting on the research Dr Matt Sleeman, Senior Director of Biology at MedImmune said: "Not only is this a great observation that can influence how we as a biotech company identify and design future therapies, it also shows the innovative 'out of the box' thinking that can be achieved by working in close partnership with academics at the top of their field. This unique partnership, bringing together industry and academia, demonstrates a real catalyst of scientific change within the UK, and I am excited by the potential of the MCCIR to bring further innovation that could ultimately bring benefit to patients."

Much of the research for this study was carried out during Professor Davis' time at Imperial College London. He will be continuing to use high quality video imaging at a microscopic level to investigate immunology at the MCCIR.

Professor Davis and MedImmune would like to acknowledge the funding they received from the Medical Research Council which helped make this study possible.

Videos: http://bloodjournal.hematologylibrary.org/content/early/2013/04/23/blood-2013-02-482570/suppl/DC1

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Journal Reference:

1. D. Rudnicka, A. Oszmiana, D. K. Finch, I. Strickland, D. J. Schofield, D. C. Lowe, M. A. Sleeman, D. M. Davis. Rituximab causes a polarisation of B cells which augments its therapeutic function in NK cell-mediated antibody-dependent cellular cytotoxicity. Blood, 2013; DOI: 10.1182/blood-2013-02-482570

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/uNtotQMZrJk/130424102940.htm

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Liver disease: New studies demonstrates lethal link between alcohol, weight

Apr. 25, 2013 ? Research announced today at the International Liver CongressTM 2013 has revealed the deadly impact that alcohol and body weight have on liver disease.

Women should forgo the wine and doughnuts after a new study found the harmful combination of high alcohol intake and high body mass index (BMI) causes an increased risk of chronic liver disease. The study analysed a cohort of over 107,000 women to investigate how a female's weight and alcohol consumption affected their chances of suffering and dying from chronic liver disease.

EASL's Scientific Committee Member Dr. Daniele Prati said this research involved a large study to investigate the combined influence of a person's alcoholic intake and BMI on the liver.

Dr. Prati said: "It's well known that alcohol and a person's weight are major causes of chronic liver disease however there has been a need for a large population study to compare these factors' influences on each other. Interestingly, the research found the combination of a woman's drinking habits and weight has an important effect on liver health and life expectancy."

More than 107,000 women across the United Kingdom who took part in the study were classed with a low or high BMI (<25 or ? 25) and a low or high alcohol intake (between 0-15 or over 15 units per week). BMI is a measure for human body shape based on an individual's weight and height, with people scoring ? 25 classified as overweight. The study found risk was significantly increased in the group of women with a high BMI and high alcohol intake, with these participants more likely to suffer from chronic liver disease.

Dr. Prati explained: "These findings will have a significant impact on how we can help millions of people across the world at risk of developing liver disease. Women are at particular risk as they are twice as sensitive as men to alcohol related liver damage and developing a more severe form of the disease at lower doses with shorter durations of alcohol consumption. Based on this research we know that a person with low BMI and high alcoholic intake have a greater risk of developing chronic liver disease compared to a woman with a high BMI who doesn't drink very much. More research is required to determine the exact thresholds for each risk factor that independently and in combination increase the risk of chronic liver disease but this is an important first step in the right direction."

Other new research released at the congress showcased a strong link between the development of hepatocellular carcinoma (HCC) in alcoholic cirrhosis patients and metabolic fatty liver disease. The study found that patients with alcoholic cirrhosis who also have fatty liver disease and are overweight, obese or type 2 diabetic are more likely to develop HCC.

The research examined 100 patients who received transplants for alcoholic end stage liver disease to analyse the impact of both fatty liver and metabolic risk factors such as obesity and type 2 diabetes on the development of HCC in patients.

The results showed more patients with HCC had been frequently overweight (54% compared to 14% of non-HCC patients) or diabetic (43% compared to 22% of non-HCC patients). Half (50%) of patients who had fatty liver disease and were overweight, obese or had type 2 diabetes were found to have HCC compared to just 6% of patients with HCC without these other conditions.

Dr. Prati commented: "Fatty liver and alcohol have long been known as risk factors for HCC but this study tested their combined effect in patients with alcoholic cirrhosis. These findings show patients suffering from alcoholic cirrhosis who also have a history of fatty liver disease, obesity or type 2 diabetes have a higher risk of developing liver cancer. The results will be useful to improve the management of patients with cirrhosis, and to identify cancer at early stages."

Worldwide, HCC accounts for approximately 5.4% of all cancers and causes 695,000 deaths per year, including 47,000 deaths in Europe per annum.

Europe has the highest rate of alcohol consumption in the world with one in seven adults consuming more than the recommended average daily amount.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/S5ygsZKGZpU/130425091608.htm

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Today on New Scientist: 25 April 2013

Quantum effects get a weirdness scale
A ranking system for quantum effects gives us a sense of how close ? or not ? we are to realising Schr?dinger's cat

Mindscapes: The woman who was dropped into her body
Depersonalisation disorder ? in which your memories feel alien and your world unreal ? is less rare than you might think. We speak to someone who has it

Zoologger: The rat with two faces
The African ice rat is both friend and foe to its companions ? cooperative when underground in a burrow, but nasty once they go outside

Kinect plus projector makes anything a remote control
A combination of depth cameras and projectors called WorldKit lets you create zappers for TVs, room lighting, and more, on any bit of household furniture

A portrait of neon hedgehogs in a nanosphere garden
An award-winning image of brightly coloured microscopic pom-poms reveals how a novel material affects crystal growth

Humans may have reached the Americas 22,000 years ago
A controversial find of stone tools in Brazil suggests that humans somehow reached the Americas at the height of the last ice age

Stress has unexpected health benefits ? sometimes
Chronic stress can increase our risk of age-related diseases, but in the right conditions a little stress can protect against the effects of ageing

Oases of cool: Taking the heat out of urban living
Can new technology and astute planning keep our cities cool in the face of global warming? Kat Austen investigates the best ideas

Water worlds bring us closer to finding Earth's twin
A pair of planets roughly the size of Earth are adding to the diversity of life-friendly worlds we may find across the galaxy

Voice-based web access helps illiterate get online
A new internet system is giving a voice to people in Africa who cannot read or write or who lack a computer

Ice-bound hunter sees first hint of cosmic neutrinos
Two high-energy particles glimpsed by the IceCube neutrino detector may be opening the door on a new way of exploring the universe

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